The University of Santo Tomas Senior High School popularly known as UST SHS or UST Senior High, was established on 2016 to cater upon the establishment of senior high school (grades 11-12) in the Philippines.[2] It is one of the basic education schools of the University of Santo Tomas.[3]

UST SHS offers a diverse range of academic pathways through its six specialized program. Students can opt for Science, Technology, Engineering, and Mathematics Program (STEM), Business and Entrepreneurship Program, Health-Allied Program (HA), Humanities and Social Sciences Program (HUMSS), Music, Arts, and Design Program (MAD) and Physical Education and Sports Program (PES).